8-OH-HHC: A stellar discovery that changes the cosmic rules

30. 10. 2024

• A new star in the cannabinoid : what is 8-OH-HHC?
• How is 8-OH-HHC born in a space lab?
• Stereoisomers: different galaxies of one cannabinoid
• What cosmic footprint does 8-OH-HHC leave?
• What dangers lurk in orbit?
• How to navigate the galactic market?
• Conclusion

A new star in the cannabinoid sky: what is 8-OH-HHC?

In the far corners of the cannabinoid universe is a brand new discovery known as 8-OH-HHC, or 8-hydroxyhexahydrocannabinol. This cosmic name hides not only the compound itself, but also its two stereoisomers: 8-OH-9α-HHC and 8-OH-9β-HHC.

8-OH-HHC is like a shining meteor among phytocannabinoids, appearing only in trace amounts in the cannabis plant. In the cannabinoid galaxy, it is found among the primary metabolites of hexahydrocannabinol (HHC), which undergoes a cosmic transformation into a series of new metabolites as it passes through the human body. One of these metabolites that shines brightest is 8-OH-HHC.

As HHC travels through our bodies, it encounters a fleet of enzymes from the cytochrome P450 family, whose members CYP3A4, CYP2C9 and CYP2C19 are tasked with adding oxygen to the molecule. This produces so-called oxygenated derivatives, including the star cannabinoid 10-OH-HHC.

How is 8-OH-HHC born in a space lab?

Commercially available 8-OH-HHC does not come from nature, but is created in space laboratories. Scientists work with the HHC molecule and add a hydroxyl group (OH) at its core, specifically at the eighth carbon (C8), by hydroxylation. This process is carried out either with the help of specific enzymes or chemical catalysts.

This synthetic pathway produces various stereoisomers, such as 8-OH-9α-HHC and 8-OH-9β-HHC, which are molecular stars in the 8-OH-HHC constellation. Scientific ships can head to different sectors of the synthesis and create different versions of the compound depending on the direction of travel.

 

Stereoisomers: different galaxies of one cannabinoid

8-OH-HHC shines in four main forms: cis- and trans-8-OH-9α-HHC and cis- and trans-8-OH-9β-HHC. These stereoisomers differ from each other only by slight changes in molecular structure. However, even these minor differences can lead to different effects, and the 1980 study was designed to investigate how these substances affect the biological activity of cannabinoids.

In 1991, the famous chemist and professor Raphael Mechoulam, a pioneer in cannabinoid research, and his team conducted in vivo experiments on rhesus macaques. These tests revealed that the four forms studied had different levels of biological activity, with cis-8-OH-9β-HHC achieving the highest activity.

Yet it is believed that all four forms may exhibit some degree of activity.

Earlier studies have yielded interesting findings: for example, mice produce some form of 8-OH-HHC at higher levels than hamsters. This phenomenon suggests that different animal species may respond differently to cannabinoids - as if every life form on this planet has a specific cosmic biological footprint that it uses to respond to these complex molecules.

What cosmic footprint does 8-OH-HHC leave?

Like other psychoactive cannabinoids, 8-OH-HHC delivers cosmic waves of euphoria and relaxation. Its psychoactive effects are more subtle than THC or HHC, but still powerful enough to affect perception, whet the appetite and relax the mind.

8-OH-HHC interacts with the endocannabinoid system (ECS) and probably binds to CB1 and CB2 receptors.

 

There have been no interplanetary studies to fully reveal the effects of this substance, leaving room for further galactic observations.

What dangers lurk in orbit?

While a space fleet of scientists is yet to confirm the side effects of 8-OH-HHC, we don't have to be swallowed by the black hole of ignorance - we can rely on our knowledge of other psychoactive cannabinoids such as HHC, HHCP, THCB or THCJD.

Possible side effects may include:

• Dry mouth
• Reddened eyes
• Increased heart rate
• Drowsiness and dizziness
• Anxiety or paranoia

 

These effects may vary depending on the individual's sensitivity, dose and route of administration.

How to navigate the galactic market?

If you decide to explore the cannabis universe and reach for products with 8-OH-HHC, an interesting array of options awaits you.

 

 On planet Earth you will find products such as:

• 8-OH-HHC vape pens and cartridges
• 8-OH-HHC flowers
• Liqiuds (liquids for vaping)
• Prerolls
• Gummies

While there is no research on the safety of this new star, let's not forget that many cannabinoids are in the legal grey area and products may contain heavy metals or pesticides. That's why it's important to choose trustworthy vendors who test their products in independent labs and publish Certificates of Analysis (COAs).

 

Conclusion

8-OH-HHC seems to be an interesting new discovery in the cannabinoid galaxy, offering lighter psychoactive effects compared to THC or HHC. This compound is produced synthetically and exists in four stereoisomers, each with different biological effects.

Although the safety and effects of 8-OH-HHC are still under interplanetary investigation, interest in this new substance is growing. If you want to embark on this space journey, be careful and choose products from reputable manufacturers.

Avoid driving spacecraft and other spacecraft, as well as attempting interstellar travel, after taking substances with psychoactive effects.

 

Author: Cannastra 🚀

 

   

Photo: AI

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